Curriculum Vitae
May 23, 2005
FRANCIS V. CHISARI, M.D.
Professor
The Scripps Research Institute
10550 North Torrey Pines Road
La Jolla, CA 92037 USA
Phone (858) 784-8228
Fax (858) 784-2160
e-mail: fchisari@scripps.edu
Date
of Birth: April
5, 1942
Place
of Birth: New
York, New York
Citizenship: USA
Education: B.A.,
Magna cum laude, Fordham
University, 1963
M.D.,
Cornell University Medical College, 1968
Scholastic
Honors: Phi
Beta Kappa, 1963; Alpha Omega Alpha 1967
Training:
Anatomic Pathology: Fellow,
Cornell University Medical College, New York 1966-1967.
Fellow,
Mayo Clinic, Rochester, Minnesota 1969-1970.
Internal Medicine: Intern,
The New York Hospital-Cornell University Medical Center, New York, New York
1968-1969.
Resident,
Mary Hitchcock Memorial Hospital, Dartmouth Medical School, Hanover, New
Hampshire 1972-1973.
Immunopathology: Staff
Associate, Laboratory of Pathology, Division of Biological Standards, National
Institutes of Health, Bethesda, Maryland 1970-72.
Research
Fellow, Department of Experimental Pathology, Scripps Clinic and Research
Foundation, La Jolla, California
1973-1975.
Molecular
Biology: Fogarty
Scholar, Unite de Recombinaison et Expression Genetique, Institut Pasteur,
Paris, France 1983-1984.
Board Certification: Internal
Medicine, 1973; Anatomic Pathology, 1975.
National Service: United
States Public Health Service, National Institutes of Health, Bethesda,
Maryland 1970-1972.
Employment:
1975-1981 Assistant
Professor, Departments of Molecular Immunology and Clinical Research, Scripps
Clinic and Research Foundation, La Jolla, California
1976-1981 Assistant
Adjunct Professor, Department of Pathology, University of California, San Diego
School of Medicine, La Jolla, California
1981 - 1988 Associate
Professor, Department of Basic and Clinical Research, Research Institute of
Scripps Clinic, La Jolla, California
1982-1987 Associate
Adjunct Professor, Department of Pathology, University of California, San
Diego, School of Medicine, La Jolla, California
1984-1989 Associate
Director, General Clinical Research Center, Research Institute of Scripps
Clinic, La Jolla, California
1987-1998 Adjunct
Professor, Department of Pathology, University of California, San Diego, School
of Medicine, La Jolla, California
1989-2004 Director,
General Clinical Research Center, The Scripps Research Institute, La Jolla,
California
1988-Present Professor
and Head, Division of Experimental Pathology, Dept of Molecular and
Experimental Medicine, The Scripps Research Institute, La Jolla, California
Review
Committees and Advisory Boards:
-Pathology B Study Section and
Reviewers' Reserve, National Institutes of Health, 1988-1992
-Scientific Review Board, German Cancer
Research Center, Heidelberg, Germany, 1990-91
-Hepatitis Panel, US-Japan Cooperative
Medical Science Program, 1992-1998
-Hepadnaviridae Study Group,
International Committee and Taxonomy of Viruses, 1994-present
-Scientific Advisory Board, Liver
Research Ctr., Albert Einstein Coll. of Medicine, 1995-2001
-Nominating Committee, American Society
for Investigative Pathology, 1999-2002
-Distinguished Advisory Committee, UCSD
Cancer Center, 2000-present
-Scientific Advisory Board, Center for
Genetics and Genomics, Brown University, 2000-2002
-Review Panel, Int'l Research Scholars
Program, Howard Hughes Med. Inst., 2000-present
-Scientific Advisory Board, Center for
the Study of HCV, Rockefeller Univ., 2000-present
-Board of Scientific Councilors (ad
hoc), NIAID, NIH, 2001
-Blue Ribbon Panel on Bioterrorism
Research, NIAID, NIH, 2002
-Expert Panel on Immunity and
Biodefense, NIAID, NIH, 2002
-Class IV Membership Committee,
National Academy of Sciences, 2004-present
- Scientific Advisory Board, Northeast
Biodefense Center, 2004-present
Editorial Boards
(*current):
*Journal of Virology; *PLoS Pathogens; *Virology;
*Journal of Clinical Investigation; *Microbial Pathogenesis; Journal of
Immunology; American Journal of Pathology; Viral Immunology; Hepatology;
Journal of Experimental Pathology
Professional Societies:
American Society for Virology, American Association
of Immunologists, American Society for Investigative Pathology, American
Association for Cancer Research, American Association for the Advancement of
Science, Molecular Medicine Society.
Honors and Awards:
Elected
Member, Association of University Pathologists, 1978
Fogarty
Senior International Fellowship, NIH, 1983-1984.
Foreign
Scholar, Fondation pour la Recherche Medicale, Paris, France, 1984.
MERIT
Award, NIH, 1990-2000.
Elected
Member, Association of American Physicians, 1992.
Elected
Fellow, American Association for the Advancement of Science, 1996.
Ernst
Jung Prize in Medicine, Jung-Stiftung fr Wissenschaft und Forschung, Hamburg
1997.
First
Distinguished Scientific Achievement Award, American Liver Foundation, 1997.
Rous-Whipple Award, American Society for
Investigative Pathology, 1999.
Distinguished Achievement Award, American
Association for the Study of Liver Diseases,1999.
Elected Member, The Henry Kunkel Society,
1999.
Elected Fellow, American Academy of Microbiology,
2002.
Elected Member, National Academy of Sciences, 2002.
Elected Member, Institute of Medicine, National
Academy of Sciences, 2003.
Distinguished Alumnus, Weill-Cornell University
Medical College, 2004
Named
Lectureships:
Peter
Ciano Memorial Lecture, Harvard Medical School, 1992.
Henry
Moon Memorial Lecture, University of California San Francisco, April 1992.
Sheila
Sherlock Lecture in Liver Biology and Disease, University of Toronto, 1992.
Maud
L. Menten Lecture in Experimental Pathology, University of Pittsburgh, 1996.
Karl
F. Meyer Lectureship in Microbiology, University of California San Francisco,
1997.
Shipley
Symposium Lectureship in Microbial Pathogenesis, Harvard Medical School, 1997.
Bertram-Marx Lectureship in Microbiology, Univ. of
Alabama, Birmingham, 1998.
Distinguished Lecturer in Medical Sciences, Mayo
Clinic, 1999.
Bruce Witte Distinguished Lecturer, Hepatitis B
Foundation, Thomas Jefferson Univ., 2002.
Stowell Lecturer, University of California, Davis,
2002
Dean's Distinguished Lecturer, University of
Colorado, Denver, 2003.
Joseph J. Kinyoun Lecturer, National Institute of
Allergy and Infectious Diseases, 2004
NIH DirectorÕs Lecturer, National Institutes of
Health, Bethesda, 2005
S. Edward Sulkin Visiting Professor, UT Southwestern
Medical Center at Dallas, 2005
Lamb Professor of Molecular Pathogenesis, Vanderbilt
University School of Medicine, 2005
U.S. Patent 4,599,230; 4,599,231 (7/8/86)
Synthetic
hepatitis B virus vaccine including both T cell and B cell determinants.
U.S. Patent 4,683,136 (7/28/87)
Proteinaceous
antigens with conformation dependent determinants.
U.S.
Patent 5,709,995 (1/20/98)
Hepatitis
C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses.
U.S.
Patent 5,780,036 (7/14/98)
Peptides
for inducing cytotoxic T lymphocyte responses to hepatitis B virus.
U.S.
Patent 5,788,969 (8/4/98)
Peptides
for inducing cytotoxic T lymphocyte responses to hepatitis B virus.
U.S.
Patent 5,840,303 (11/24/98)
Peptides
for inducing cytotoxic T lymphocyte responses to hepatitis B virus.
U.S.
Patent 5,932,224 (8/3/99)
Peptides
for inducing cytotoxic T lymphocyte responses to hepatitis B virus.
U.S.
Patent 6,235,288
(5/22/01)
Peptides
for inducing cytotoxic T lymphocyte responses to hepatitis B virus.
U.S.
Patent 6,607,727 (8/19/03)
Peptides
for inducing cytotoxic T lymphocyte responses to hepatitis B virus.
*Epimmune,
San Diego, CA
*Gilead
Sciences, Foster City, CA
*Nucleonics,
Inc., Horsham, PA
*Valeant
Pharmaceuticals International, Costa Mesa, CA
Avant Immunotherapeutics,
Needham, MA
Aventis Pharmaceuticals,
Bridgewater, NJ
Centocor Inc., Malvern, PA
Cytel Inc., La Jolla, CA
DNX Inc., Princeton, NJ
Genencor International, Palo
Alto, CA
Genentech, South San Francisco,
CA
Isis Pharmaceuticals,
Carlsbad, CA
Pfizer/Agouron, San Diego, CA
SmithKline Beecham, King of
Prussia, PA
Targeted Genetics, Seattle,
WA
Zycos Inc, Lexington, MA
BOOKS
1. The
Consumer's Guide to Health Care.
F.V. Chisari, R.M. Nakamura, L. Thorup, eds. Little, Brown and Company; Boston,
MA, 1976.
2. Advances
in Hepatitis Research. Francis V.
Chisari, Editor. Masson Publishing Co. Inc., New York, NY, 1984.
3. Transgenic
Models of Human Viral and Immunological Disease. Current Topics in Microbiology and Immunology. F.V. Chisari and M.B.A. Oldstone, eds.
Springer-Verlag, Heidelberg, Germany, 1995.
4. The
Liver: Biology and Pathobiology, 4th
Edition. I.M. Arias, J. Boyer, F.V. Chisari, N. Fausto, D.
Schachter and D. Shafritz,
eds. Lippincott, Williams &
Wilkins, Philadelphia, PA, 2001.
PAPERS
1. Grossman,
H., Winchester, P.H., and Chisari, F.V. Roentgenographic classification of
renal cystic disease. J. Immunol. 104:319-331, 1968.
2. Deal,
D.R., Gerber, P., and Chisari, F.V. Heterotransplantation of two human lymphoid
cell lines transformed in vitro by Epstein-Barr virus. J. Nat'l. Cancer Inst.
47:771-780, 1971.
3. Northrup,
R.S., and Chisari, F.V. Response of monkeys to immunization with cholera
toxoid, toxin, and vaccine: reversion of cholera toxoid. J. Infect. Dis.
125:471-479, 1972.
4. Northrup,
R.S., and Chisari, F.V. Cholera toxoid reactions in human volunteers: clinical
and histological studies. Prog. Immunol. Stand. 5:355-364,1972.
5. Chisari,
F.V., Hochstein, H.D., Kirschstein, R.L., and Seligmann, E.B. Parathyroid
necrosis and hypocalcemic tetany induced in rabbits by L-asparaginase. Am. J.
Pathol. 68:461-468, 1972.
6. Barker,
L.F., Chisari, F.V., McGrath, P.P., Dalgard, D.W., Kirschstein, R.L., Almeida,
J.D., Edgington, T.S., Sharp, D.G., and Peterson, M.R. Transmission of type B
viral hepatitis to chimpanzees. J.
Infect. Dis. 127 :648-662, 1973.
7. Friedlander,
M.H., Chisari, F.V., and Baer, H. The role of the inflammatory response of skin
and lymph nodes in the induction of sensitization to simple chemicals. J.
Immunol. 111:164-170, 1973.
8. Chisari,
F.V., Gerin, J.L., and Edgington, T.S. Immunochemistry of the hepatitis B
virus: 125I HBsAg ligand. J. Immunol.
113:543-553, 1974.
9. Chisari,
F.V., Northrup, R.S., and Chen, L.C. The modulating effect of cholera
enterotoxin on the immune response. J. Immunol. 113:729-739, 1974.
10. Chisari,
F.V. and Northrup, R.S. Pathophysiologic effects of lethal and immunoregulatory
doses of cholera enterotoxin in the mouse. J. Immunol. 113:740-749, 1974.
11. Chisari,
F.V., and Edgington, T.S. Human T lymphocyte E rosette function. I. A process
modulated by intracellular cyclic AMP. J. Exp. Med. 140:1122-1126, 1974.
12. Nakamura,
R.M., Chisari, F.V., and Edgington, T.S. Laboratory tests for diagnosis of
autoimmune diseases. Prog. Clin. Pathol. 6:177-203, 1975.
13. Edgington,
T.S., and Chisari, F.V. Immunological aspects of hepatitis B virus infection.
Am. J. Med. Sci. 270:212-227, 1975.
14. Chisari,
F.V., and Edgington, T.S. Lymphocyte E rosette inhibitory factor: A regulatory
serum lipoprotein. J. Exp. Med. 142:1092-1107, 1975.
15. Chisari,
F.V., Routenberg, J.A., and Edgington, T.S. Mechanisms responsible for
defective human T-lymphocyte sheep erythrocyte rosette function associated with
hepatitis B virus infections. J. Clin. Invest. 57:1227-1238, 1976.
16. Edgington,
T.S., Chisari, F.V., and Curtiss, L.K. Regulation of lymphocyte function in HBV
infection. In: Immunopathology:
VII International Symposium, Lindau, West Germany, Miescher, P. (Eds.). Schwabe
and Co., Stuttgart, pp. 173-190, 1977.
17. Chisari,
F.V., Routenberg, J.A., Fiala, M., and Edgington, T.S. Extrinsic modulation of
human T-lymphocyte E rosette function associated with prolonged hepatocellular
injury after viral hepatitis. J. Clin. Invest. 59:134-142, 1977.
18. Chisari,
F.V., Gealy, W.J., and Edgington, T.S. Recovery of soluble sheep erythrocyte
receptor from the T lymphocyte surface by proteolytic cleavage. J. Immunol.
118:1138-1142, 1977.
19. Chisari,
F.V. Immunoregulatory properties of human plasma very low density lipoproteins.
J. Immunol. 119:2129-2136, 1977.
20. Edgington,
T.S., and Chisari, F.V. Immune responses to hepatitis B virus coded and induced
antigens in chronic active hepatitis. In Immune Reactions in Liver Disease.
Eddleston, A., and Williams, R., eds. Pitman Medical, England, pp. 44-60, 1979.
21. Chisari,
F.V., Edgington, T.S., Routenberg, J.A., and Anderson, D.S. Cellular immune
reactivity in hepatitis B virus-induced liver disease. In: Viral Hepatitis. Vyas, G.N., Cohen, H.N., and
Schmid, R. (Eds.). Franklin Institute Press, Philadelphia, 1978.
22. Chisari,
F.V., and Edgington, T.S. An integrating immunoregulatory hypothesis for the
immunopathogenesis of liver disease associated with hepatitis B virus
infection. In: Persistent
Viruses, Volume XI. Stevens, J., Todaro, G.J., and Fox, C.F. (Eds.). Academic
Press, New York, pp. 499-520, 1978.
23. Chisari,
F.V. Regulation of human lymphocyte function by a soluble extract from normal
human liver. J. Immunol. 121:1279-1286, 1978.
24. Knecht,
G.L., and Chisari, F.V. Reversibility of hepatitis B virus-induced
glomerulonephritis and chronic active hepatitis after spontaneous clearance of
serum hepatitis B surface antigen. Gastroenterology 75:1152-1156, 1978.
25. Chisari,
F.V. Immunoflourescent analysis of tissue and serum for hepatitis B virus
markers. In: Immunoassays in the
Clinical Laboratory. Nakamura, R.M., Dito, W.R., and Tucker III, E.S. (Eds.).
Alan R. Liss, Inc., New York, pp. 173-183,1979.
26. Routenberg,
J.A., Dienstag, J.L., Harrison, W.O., Kilpatrick, M.E., Hooper, R.R., Chisari,
F.V., Purcell, R.H., and Fornes, M.F. Foodborne outbreak of hepatitis A:
Clinical and laboratory features of acute and protracted illness. Am J. Med.
Sci. 278:123-137, 1979.
27. Mohagheghpour,
N., Parhami, B., Dowlatshahi, K., Kadjehnourii, D., Elder, J.H., and Chisari,
F.V. Immunoregulatory properties of human esophageal tumor extract. J. Immunol.
122:1350-1358, 1979.
28. Chisari,
F.V. Immunoregulatory lipoproteins, viral hepatitis and cancer. In: Atherosclerosis. Gotto, A.M., Smith, L.C., and
Allen, B. (Eds.). Springer-Verlag, New York, pp. 340-347, 1979.
29. Chisari,
F.V. Liver-specific protein in perspective. Gastroenterology 78:168-170, 1980.
30. Chisari,
F.V., Modulation of the in vivo immune response by human plasma very
low-density lipoproteins. Cell Immunol. 52:223-253, 1980.
31. Chisari,
F.V., Cellular immunoassays: Investigative tools in clinical research. In: Clinical Laboratory Techniques for the 1980's.
Nakamura, R.M. (Ed.). Alan R. Liss, Inc., New York, NY, pp. 235-253, 1980.
32. Michelson,
J.B., Michelson, P.E., and Chisari, F.V. Subretinal neovascular membrane and
disciform scar in Behcet's disease. Am. J. Ophthalmol. 90:182-185, 1980.
33. Chisari,
F.V., Castle, K.L., Xavier, C. and Anderson, D.S. Functional properties of
lymphocyte subpopulations in hepatitis B virus infection. I. Suppressor cell
control of T lymphocyte responsiveness. J. Immunol. 126:38-44, 1981.
34. Chisari,
F.V., Bieber, M.S., Josepho, C.A., Xavier, C., and Anderson, D.S. Functional
properties of lymphocyte subpopulations in hepatitis B virus infection. II.
Cytotoxic effector cell killing of targets that naturally express hepatitis B
surface antigen and liver-specific lipoprotein. J. Immunol. 126:45-49, 1981.
35. Michelson,
J.B., Michelson, P.E., Bordin, G.M., and Chisari, F.V. Ocular reticulum cell
sarcoma. Presentation as retinal detachment with demonstration of monoclonal
immuno-globulin light chains on the vitreous cells. Arch. Ophthalmol.
99:1409-1411, 1981.
36. Levy,
G.A. and Chisari, F.V. The immunopathogenesis of chronic HBV induced liver
disease. Springer Seminar Immunopathol. 3:439-459, 1981.
37. Levy,
G.A. and Chisari, F.V. A proposed role for the immune system in the
pathogenesis of hepatitis B virus induced liver disease. CRC Crit. Rev. Clin.
Lab. Sci. 15:335-353, 1981.
38. Levy,
G.A. and Chisari, F.V. Cellular and molecular interactions responsible for
hepatocellular injury in viral hepatitis. In: Recent Progress in Clinical Laboratory Immunology.
Nakamura, R.M. (Ed.). Masson Publishing Company, New York, pp. 115-128, 1981.
39. Chisari,
F.V., Curtiss, L.K., and Jensen, F.C., Physiologic concentrations of normal
human plasma lipoproteins inhibit the immortalization of peripheral B
lymphocytes by the Epstein-Barr virus. J. Clin. Invest. 68:329-336, 1981.
40. Chisari,
F.V. and Curtiss, L.K. Modulation of peripheral blood mononuclear cell cyclic
adenosine monophosphate levels by human very low density lipoproteins. Cell
Immunol. 65:325-336, 1981.
41. Michelson,
J.B. and Chisari, F.V. Behcet's disease. Surv. Ophthalmol. 26:190-203, 1982.
42. Chisari,
F.V. and Nowoslawski, A. Immunology and pathogenesis of viral hepatitis. In: Proc. of 3rd Internatl. Symp. on Viral Hepatitis.
The Franklin Institute Press, Philadelphia, pp. 779-783, 1982.
43. Pizzo,
C., Lee, D., and Chisari, F.V. Suppression of lymphocyte activation by a
protein released from isolated perfused rat liver. Hepatology 2:295-303, 1982.
44. Sobol,
R.E., Astarita, R.W., Chisari, F.V., Griffiths, J.C. and Royston, I. Use of
immuno-globulin light chain analysis to detect bone marrow involvement in
B-cell neoplasms. Clin. Immunol. Immunopathol. 24:139-144, 1982.
45. Chisari,
F.V. Regulation of lymphocyte function and viral transformation by hepatic
bioregulatory molecules. Hepatology 2:97S-106S, 1982.
46. Milich,
D.R. and Chisari, F.V. Genetic regulation of the immune response to hepatitis B
surface antigen (HBsAg). I. H-2 restriction. J. Immunol. 129:320-325, 1982.
47. Huddlestone,
J. and Chisari, F.V. Function of lymphocytes and plasma cells in immunity. In: Hematology. Williams, W.J., Beutler, E., Erslev,
A.J., and Lichtman, M.A. (Eds.). McGraw Hill, New York, pp. 915-922, 1983.
48. Nichols,
W.S., and Chisari, F.V. Structure and function of the lymphoreticular system. In: Hematology. Williams, W.J., Beutler, E., Erslev,
A.J., and Lichtman, M.A. (Eds.). McGraw Hill, New York, 1983.
49. Parks,
D.E., and Chisari, F.V. Production and distribution of lymphocytes and plasma
cells. In: Hematology. Williams,
W.J., Beutler, E., Erslev, A.J., and Lichtman, M.A. (Eds.). McGraw Hill, New
York, 1983.
50. Milich,
D.R., Leroux-Roels, G.G., and Chisari, F.V. Genetic regulation of the immune
response to hepatitis B surface antigen (HBsAg). II. Qualitative
characteristics of the humoral immune response to the a, d, and y determinants
of HBsAg. J. Immunol. 130:1395-1400, 1983.
51. Milich,
D.R., Alexander, H., and Chisari, F.V. Genetic regulation of the immune
response to hepatitis B surface antigen (HBsAg). III. Circumvention of
nonresponsiveness in mice bearing HBsAg nonresponder haplotypes. J. Immunol.
130:1401-1407, 1983.
52. Leroux-Roels,
G.G., Milich, D.R., and Chisari, F.V. Suppression of the acute
graft-versus-host reactin in mice by in vitro or in vivo allosensitization in
the presence of cyclosporin A. In:
Intercellular Communications in Leucocyte Function. Wiley, J.W., and O'Brien,
R.L. (Eds.). John Wiley & Sons, Ltd., pp. 627-630, 1983.
53. Chisari,
F.V., Hepatic immunoregulatory molecules and the pathogenesis of hepatocellular
injury in viral hepatitis. In: Advances
in Hepatitis Research. Chisari, F.V., (Ed.). Masson Publishing Company, New
York, pp. 168-178, 1984.
54. Milich,
D.R. and Chisari, F.V. Immunogenetics and cellular correlates of the immune
response to HBsAg determinants. In: Advances in Hepatitis Research. Chisari, F.V. (Ed.). Masson Publishing
Company, New York, pp. 91-109, 1984.
55. Molden,
D.P. and Chisari, F.V. Immunologic diagnosis of hepatitis virus infection.
College of American Pathologists
Conference on Immunology, Steamboat, CO, August 1983. In: Diagnostic Immunology Technology Assessment and
Quality Assurance. Rippey, J.H. and Nakamura, R.M. (Eds.). College of American
Pathologists, Publishers, Skokie, IL, p. 229, 1984.
56. Chisari,
F.V., Milich, D.R. and Tiollais, P. Hepatitis B virus infection: a model for
immunologically mediated hepatocellular injury. In: Mechanisms of Hepatocyte Injury and Death. Keppler,
D., Reutter, W. and Bianchi, L. (Eds.) MTP Press Limited, Lancaster, PA, p.
293, 1984.
57. Kasahara,
Y., Leroux-Roels, G.G., Nakamura, R. and Chisari, F.V.
Glycylprolyldiamino-peptidase in human leukocytes: selective occurrence in T
lymphocytes and influence on the total serum enzyme activity. Clin. Chim. Acta.
139:295-302, 1984.
58. Milich,
D.R., Peterson, D.L. and Chisari, F.V. Comparisons of T cell and B cell immune
recognition of HBsAg. In: Proceedings
of the 4th International Symposium on Viral Hepatitis. Vyas, G.N., Dienstag,
and Hoofnagle, J. (Eds.). Grune & Stratton, Inc., Orlando, FL, pp. 573-582,
1984.
59. Milich,
D.R., Leroux-Roels, G.G., Louie, R.E., and Chisari, F.V. Genetic regulation of
the immune response to hepatitis B surface antigen (HBsAg). IV. Distinct
H-2-linked genes control antibody responses to different HBsAg determinants on
the same molecule and map to the I-A and I-C subregions. J. Exp. Med.
159:41-56, 1984.
60. Michelson,
J.B., Chisari, F.V., and Kansu, T. Antibodies to oral mucosa in patients with
ocular Behcet's disease. Amer. J. Ophthalmol. 92:1277-1281, 1985.
61. Milich,
D.R., Louie, R.E. and Chisari, F.V. Genetic regulation of the immune response
to hepatitis B surface antigen (HBsAg) V. T cell proliferative response and
cellular interactions. J. Immunol.
134:4194-4202, 1985.
62. Milich,
D.R., Peterson, D.L., Leroux-Roels, G.G., Lerner, R.A., and Chisari, F.V.
Genetic regulation of the immune response to hepatitis B surface antigen
(HBsAg). VI. T cell fine specificity. J. Immunol. 134:4203-4211, 1985.
63. Milich,
D.R., Thornton, G.B., Neurath, A., Kent, S., Michel, M., Tiollais, P., and
Chisari, F.V. Enhanced immunogenicity of the pre-S region of hepatitis B
surface antigen. Science 228:1195, 1985.
64. Chisari,
F.V., Nakamura, M., Milich, D.R., Han, K., Molden, D., and Leroux-Roels, G.G.
Production of two distinct and independent hepatic immunoregulatory molecules
by the perfused rat liver. Hepatology 5:735-743,1985.
65. Chisari,
F.V., Pinkert, C.A., Milich, D.R., Filippi, P., McLachlan, A., Palmiter, R.D.,
and Brinster, R.L. A transgenic mouse model of the chronic hepatitis B surface
antigen carrier state. Science 230:1157-1160, 1985.
66. Milich,
D.R., McNamara, M., McLachlan, A., Thornton, G., and Chisari, F.V. Distinct
H-2-linked regulation of T cell responses to the pre-S and S regions of the
same HBsAg polypeptide allows circumvention of the S region nonresponsiveness.
Proc. Nat'l. Acad. Sci. USA 82:8168-8172, 1985.
67. Michel,
M.-L., Milich, D.R., Chisari, F.V., and Tiollais, P. Synthesis in CHO cells of
hepatitis B surface antigen particles containing synthetic pre-S(2) region
expression product. In: Vaccines
'86. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, pp.359-363, 1986.
68. Milich,
D.R., Thornton, G.B., McLachlan, A., McNamara, M., and Chisari, F.V. T and B
cell recognition of native and synthetic pre-S(2) region determinants on HBsAg.
In: Vaccines '86. Cold Spring
Harbor Press, Cold Spring Harbor, NY, pp. 377-382, 1986.
69. Milich,
D.R., McLachlan, A., Chisari, F.V., Kent, S.B.H., and Thornton, G.B. Immune
response to the pre-S(l) region of the hepatitis B surface antigen (HBsAg): A
pre-S(l)-specific T cell response can bypass nonresponsiveness to the pre-S(2)
and S regions of the HBsAg. J. Immunol. 137:315-322, 1986
70. Milich,
D.R., McLachlan, A., Chisari, F.V., and Thornton, G.B. Nonoverlapping T and B
cell determinants on an hepatitis B surface antigen (HBsAg) pre-S(2) region
synthetic peptide. J. Exp. Med. 164(2):532-547,1986.
71. Milich,
D.R., McLachlan, A., Chisari, F.V., Nakamura, T., and Thornton, G.B. Two
distinct but overlapping antibody binding sites in the pre-S(2) region of HBsAg
localized within 11 continuous residues. J. Immunol. 137:2703-2710, 1986.
72. Chisari,
F.V., Filippi, P., McLachlan, A., Milich, D.R., Riggs, M., Lee, S., Palmiter,
R.D., Pinkert, C.A., and Brinster, R.L. Expression of hepatitis B virus large
envelope polypeptide inhibits hepatitis B surface antigen secretion in transgenic
mice. J. Virol. 60:880-887, 1986.
73. Ferrari,
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199. Kaplanski,
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202. Livingston,
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210. Hu,
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211. Chisari,
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213. Nakamoto,
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214. Lemon,
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215. Shimizu,
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216. Bertoni,
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217. Alexander, J., Del Guercio, M-F., Fikes, J.D., Chesnut, R.W., Chisari, F.V., Chang, K-M., Appella, E., and Sette, A. Recognition of a novel naturally processed, A2 restricted, HCV-NS4 epitope triggers IFN-gamma release in absence of detectable cytopathicity. Hum. Immunol. 59:776-782, 1998.
218. Ishikawa, T., Kono, D., Chung, J., Fowler, P.,
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219. Rehermann,
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220. Alexander,
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221. Chisari,
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222. Heise,
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223. Chang,
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224. Chisari,
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225. Schultz,
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226. Livingston, B.D., Alexander, J., Crimi, C., Oseroff, C., Vadi, R., Celis, E., Daly, K., Guidotti, L.G., Chisari, F.V., Fikes, J., Chesnut, R.W., and Sette, A. Altered helper T lymphocyte (HTL) function associated with chronic HBV infection and its role in response to therapeutic vaccination in humans. J. Immunol. 162:3088-3095, 1999.
227. Chemin,
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230. Chang,
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232. Heise,
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233. Schultz,
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234. Cerny,
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235. Guidotti, L.G. and Chisari, F.V. Cytokine induced viral purging- role in viral pathogenesis. Curr. Opin. In Microbiol. 2:388-391, 1999.
236. Reifenberg, K., Wilts, H., Lhler, J., Nusser, P., Hanano, R., Barsig, J., Guidotti, L.G., Chisari, F.V., and Schlicht, H-J. The hepatitis B virus X-protein transactivated viral core gene expression in vivo. J. Virol. 73: 10399-10405, 1999.
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238. Lauvau, G., Kakimi, K., Niedermann, G., Ostankovitch, M., Yotnda, P., Chisari, F.V., and van Endert, P. Human transporters associated with antigen processing (TAPs) select epitope precursor peptides for processing in the endoplasmic reticulum and presentation to T cells. J. Exp. Med. 190:1227-40, 1999.
239. McClary, H., Koch, R., Chisari, F.V., and Guidotti, L.G. Relative sensitivity of hepatitis B virus and other hepatotropic viruses to the antiviral effects of cytokines. J. Virol. 74:2255-2264, 2000.
240. Chisari,
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241. Wieland,
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242. Schirmbeck,
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243. Guidotti,
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244. McClary,
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247. Voehringer,
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248. Pasquetto, V.,
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249. Kakimi, K.,
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250. McKinney, D.M.,
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251. Forns, X.,
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254. Sette, A.,
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256. Thimme, R.,
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258. Heise, T., Guidotti, L.G., and Chisari, F.V. Characterization of nuclear ribonucleases that cleave hepatitis B virus RNA near the La protein binding site. J. Virol. 75:6874-6883, 2001.
259. Thimme, R., Oldach, D., Chang, K.M., Steiger, C., Ray, S., and Chisari, F.V. Determinants of viral clearance and persistence during acute HCV infection. J. Exp. Med. 194:1395-1406, 2001.
260. Kakimi, K., Lane, T.E., Chisari, F.V., and Guidotti, L.G.
Inhibition of hepatitis B virus replication by activated NKT cells does not
require inflammatory cell recruitment to the liver. J. Immunol. 167:6701-6705, 2001.
261.
Kakimi, K.,
Campbell, I., Lane, T., Wieland, S.F., Chisari, F.V., and Guidotti, L.G. Blocking chemokine responsive to g-2/interferon
(IFN)-g inducible protein and monokine induced by IFN-g activity in
vivo reduces the pathogenetic but not the antiviral potential of hepatitis B
virus-specific cytotoxic T lymphocytes.
J. Exp. Med. 194:1755-1766, 2001.
262.
Mosier, D.E. and
Chisari, F.V. GB and virus C and
mortality from HIV infection. N.
Engl. J. Med. 346:377-379, 2002.
263.
Guidotti LG, Morris A,
Mendez H, Koch R, Silverman RH, Williams BR, and Chisari FV.
Interferon-regulated pathways that control hepatitis B virus replication in
transgenic mice.
J Virol. 76:2617-21, 2002.
264.
Robek, M.D., Wieland,
S.F., and Chisari, F.V. Inhibition
of hepatitis B virus replication by interferon requires proteasome activity. J.
Virol. 76:3570-3574, 2002.
265. Pasquetto, V., Wieland, S.F., Uprichard, S.L., Tripodi, M., and Chisari, F.V. Cytokine sensitive replication of hepatitis B virus in immortalized mouse hepatocyte cultures. J. Virol. 76:5646-5653, 2002.
266. Su, A.I., Guidotti, L.G., Pezacki, J.P., Chisari, F.V., and Schultz, P.G. Gene expression during the priming phase of liver regeneration after partial hepatectomy in mice. Proc. Nat'l. Acad. Sci. USA, 99:11181-11186, 2002.
267. Kakimi, K., Chung, J.S., and Chisari, F.V. Immunogenicity and tolerogenicity of hepatitis B viral structural and nonstructural proteins: Implications for immunotherapy of persistent viral infections. J. Virol. 76:8609-8620, 2002.
268. Bukh, J., Forns, X., Thimme, R., Govindarajan, S., Miller, R.H., Emerson, S.U., Chisari, F.V., and Purcell, R.H. Analysis of the hypervariable region 1 of hepatitis C virus. In: Viral Hepatitis and Liver Disease. Margolis, H.W., Alerter, M.J., Linage, T.H. and Dynast, J.L. (Eds.). International Medical Press, pp 330-335, 2002.
269.
Bukh, J., Thimme, R.,
Govindarajan, S., Forns, X., Satterfield, W., Deer, G., Chang, K-M., Yang, M.,
Emerson S.U., Chisari, F.V., and Purcell, R.H. Monoclonal hepatitis C virus infection in chimpanzees. In: Viral Hepatitis and Liver Disease. Margolis, H.W., Alter, M.J., Liang, T.J., and Dienstag, J.L. (Eds.)
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270.
Thimme, R., Bukh, J.,
Pemberton, J., Guidotti, L.G., Purcell, R.H., and Chisari, F.V.
T-cell responses and intrahepatic cytokine profiles in HBV- and
HCV-infected chimpanzees. In: Viral Hepatitis and Liver Disease. Margolis, H.S., Alter, M.J., Liang,
T.J. and Dienstag, J.L. (Eds.). International Medical Press, 175-178, 2002.
271. Kimura, K., Kakimi, K., Wieland, S., Guidotti, L.G., and Chisari, F.V. Interleukin-18 inhibits hepatitis B virus replication in the liver of transgenic mice. J. Virol. 76:10702-10707, 2002.
272.
Sitia, G., Isogawa, M.,
Kakimi, K., Wieland, S.F., Chisari, F.V., and Guidotti, L.G. Depletion of Neutrophils Blocks the
Recruitment of Antigen Non-Specific Cells into the Liver without Affecting the
Antiviral Activity of Hepatitis B Virus-Specific Cytotoxic T Lymphocytes. Proc. Nat'l. Acad. Sci. USA. 99:13717-13722, 2002.
273.
Yang, P.L., Althage,
A., Chung, J., and Chisari, F.V.
Hydrodynamic transfection:
a mouse model of acute hepatitis B virus infection. Proc. Nat'l. Acad.
Sci. USA. 99:13825-13830, 2002.
274.
Kimura, K., Kakimi, K.,
Wieland, S., Guidotti, L., and Chisari, F.V. Activated intrahepatic antigen presenting cells inhibit
hepatitis B virus replication in the liver of transgenic mice. J. Immunol. 169:5188-5195, 2002.
275.
Thimme, R., Bukh, J.,
Wieland, S., Pemberton, J., Steiger, C., Ghrayeb, J., Reimann, K.A., Purcell,
R.H., and Chisari, F.V. Viral and
immunological determinants of HCV clearance, persistence and disease. Proc.
Nat'l Acad. Sci. USA. 99:15661-15668, 2002.
276.
Su, A.I., Pezacki,
J.P., Wodicka, L., Brideau, A.D., Supekova, L., Thimme, R., Wieland, S., Bukh,
J., Purcell, R.H., Schultz, P.G., and Chisari, F.V. Genomic analysis of the
host response to hepatitis C virus infection. Proc. Nat'l Acad. Sci. USA.
99:15669-15674, 2002.
277.
Blackman, M.A., Rouse
B.T., Chisari, F.V., and Woodland, D.L. Viral immunology: Challenges associated
with the progression from bench to clinic. Trends Immunol. 23:565-567, 2002.
278.
Thimme, R., Wieland,
S., Steiger, C., Ghrayeb, J., Reimann, K.A., Purcell, R.H., and Chisari, F.V.
CD8+ T cells mediate viral clearance and disease and pathogenesis during acute
hepatitis B virus infection. J. Virol. 77:68-76, 2003.
279.
Wieland, S.F., Vega,
R., Mller, R., Evans, C., Hilbush, B., Guidotti, L.G., Sutcliffe, J.G.,
Schultz, P.G., and Chisari, F.V. Searching for interferon-induced genes that
inhibit hepatitis B virus replication in transgenic mouse hepatocytes. J. Virol. 77:1227-1236, 2003.
280.
Uprichard, S.L.,
Wieland, S.F., Althage, A., and Chisari, F.V. Transcriptional and posttranscriptional
control of hepatitis B virus gene expression. Proc. Nat'l. Acad. Sci. USA.
100:1310-1315, 2003
281.
Kapadia, S.B.,
Brideau-Andersen, A., and Chisari, F.V. Interference of hepatitis C virus
replication by short interfering RNA. Proc. Nat'l Acad. Sci. USA.
100:2014-2018, 2003.
282.
Robek, M.D., Boyd,
B.S., Wieland, S.F., and Chisari, F.V. Signal transduction pathways that
inhibit hepatitis B virus replication. Proc. Nat'l Acad. Sci. USA.
101:1743-1747, 2004
283.
Wieland, S.F.,
Spangenberg, H-C, Purcell, R.H., and Chisari, F.V. Expansion and contraction of the hepatitis B virus
transcriptional template in acutely infected chimpanzees. Proc. Nat'l Acad.
Sci. USA. 101:2129-2134, 2004
284.
Wieland, S.W., Thimme,
R., Purcell, R.H., and Chisari, F.V. Genomic analysis of the host response to
hepatitis B virus infection. Proc. Nat'l Acad. Sci. USA. 101:6669-6674, 2004
285.
Sitia, G., Isagawa, M.,
Iannacone, M., Campbell, I., Chisari, F.V., and Guidotti, L.G. Matrix MMPs are
required for the recruitment of lymphomononuclear cells into the liver by CTLs.
J. Clin. Invest. 113:1158-1167. 2004.
286.
Chen, M., Billaud,
J-N., Sllberg, M.. Guidotti, L.G., Chisari, F.V., Jones, J., Hughes, J., and
Milich, D.R. A function of the hepatitis B virus precore protein is to regulate
the immune response to the core antigen. Proc. Nat'l Acad. Sci. USA. 101:14912-14918, 2004.
287.
Uprichard, S.L., Boyd,
B., Althage, A., and Chisari, F.V.
Clearance of ongoing hepatitis B virus gene expression and replication
in the liver of transgenic mice by short hairpin RNAs. Proc. Nat'l Acad. Sci.
USA. 102:773-774, 2005.
288.
Neumann-Haefelin, Blum,
H.E., Chisari, F.V., and Thimme R. T cell response in hepatitis C virus
infection. J. Clin Virol. 32:75-85, 2005.
289.
Kapadia, S.B. and
Chisari, F.V. Hepatitis C virus RNA replication is regulated by
geranylgeranylation and fatty acids. Proc. NatÕl Acad. Sci. USA. 102:2561-2566, 2005.
290.
Chen, M., Sllberg, M.
Hughes, J., Jones, J., Guidotti, L.G., Chisari, F.V., Billaud, J-N., and
Milich, D.R. Split immune
tolerance between the hepatitis B virus precore and core proteins. J.Virol. 79:3016-3027, 2005.
291.
Isogawa, M., Kakimi,
K., Kamamoto, H., Protzer, U., and Chisari, F.V. Differential dynamics of the
peripheral and intrahepatic cytotoxic T lymphocyte response to hepatitis B
surface antigen. Virology
333:293-300, 2005.
292.
Robek, M., Boyd, B.,
and Chisari, F.V.
Interferon-Lambda inhibits hepatitis B and C virus replication. J. Virol. 79:3851-3854. 2005.
293.
Sitia, G., Iannacone,
M., Chisari, F.V., and Guidotti, L.G. Pathogenesis of hepatitis B virus in
transgenic mice. In:
Monographs in Virology: Models of Viral Hepatitis. Roggendorf, M., (Ed.); Doerr, D.W.,
(Series Ed.). S.Karger AG, Medical and Scientific Publishers, Basel,
Switzerland, Vol. 25, pp 23-32, 2005.
294.
Thimme, R., Bukh, J.,
Spangenberg, H.C., Blum, H.E., Wieland, S.F., Purcell, R.H., and Chisari,
F.V. T cell response to hepatitis
B and C virus: Lessons learned from the chimpanzee model. In:
Monographs in Virology:
Models of Viral Hepatitis. Roggendorf, M., (Ed.); Doerr, D.W., (Series
Ed.). S.Karger AG, Medical and Scientific Publishers, Basel, Switzerland, Vol.
25, pp 66-80, 2005.
295.
Isogawa, M., Robek,
M.D., Furuichi, Y., and Chisari, F.V.
Toll-Like receptor signaling inhibits hepatitis B virus replication in
vivo. J. Virol. In press.
296.
Chisari, F.V., Thimme,
R., Guidotti, L.G., Wieland, S.F. and Purcell, R. Mediators of recovery from
HBV infection. In: Proceedings of the 11th International
Symposium on Viral Hepatitis and Liver disease. Jilbert, A.R., Grgacic, E.V.L., Vickery, K., and
Cossart, Y.E. (Eds.) The Australian Centre for Hepatitis Virology, Melbourne,
Australia. In press.
297.
Sakai, A., Thimme, R.,
Spangenberg, H.C., Govindarajan, S, Emerson, S.U., Purcell, R.H., Chisari,
F.V., and Bukh, J. Rapid
emergence of virus variants in acute HCV with vigorous host cellular immune
responses and different outcome. In
Proceedings of the 11th International Symposium on Viral
Hepatitis and Liver Disease. The
Australian Centre for Hepatitis Virology, Melbourne, Australia. Editors: AR
Jilbert, EVL Grgacic, K. Vickery, YE Cossart. In press.
298.
Bukh, J., Thimme, R.,
Satterfield, W., Meunier, J.C., Spangenberg, H.C., Forns, X., Chang, K.M.,
Emerson, S.U., Chisari, F.V., and Purcell, R.H. Persistence of HCV after homologous monoclonal re-challenge
is associated with emergence of virus variants. In: Proceedings of the 11th International
Symposium on Viral Hepatitis and Liver disease. Jilbert, A.R., Grgacic, E.V.L., Vickery, K., and
Cossart, Y.E. (Eds.) The Australian Centre for Hepatitis Virology, Melbourne,
Australia. In press
299.
Kakimi, K., Isogawa,
M., Kamamoto, H., Protzer, U., Moriyasu, F., and Chisari, F.V. Rapid
compartmentalization of virus specific cytotoxic T lymphocytes in the liver
during hepatitis B virus infection. In: Proceedings of the 11th International Symposium on Viral
Hepatitis and Liver disease. Jilbert, A.R., Grgacic, E.V.L.,
Vickery, K., and Cossart, Y.E. (Eds.) The Australian Centre for Hepatitis
Virology, Melbourne, Australia. In
press.
300.
Kimura, K., Kakimi, K.,
Wieland, S., Guidotti, L.G., Moriwaki, H. and Chisari, F.V. The role of innate
immunity against hepatitis B virus replication in the liver of transgenic mice.
In: Proceedings of the 11th
International Symposium on Viral Hepatitis and Liver disease. Jilbert, A.R., Grgacic, E.V.L., Vickery, K., and
Cossart, Y.E. (Eds.) The Australian Centre for Hepatitis Virology, Melbourne,
Australia. In press
301.
Guidotti, L.G., and
Chisari, F.V. Immunobiology and Pathogenesis of Viral Hepatitis In: Annual Review of Pathology: Mechanisms of Disease,
Volume 1; Annual Reviews. Abbase, A.K., Downing, J.R., and Kumar, V. (Eds.). Palo Alto, CA. In press
302.
Chisari, F.V. and
Wieland, S.F. Stealth and Cunning: Hepatitis B and Hepatitis C. J. Virology, In Press
303.
Bui, H., Sidney, J.,
Bjoern, P., Sathiamurthy, M., Moth, Chisari, F.V., Watkins, D.I., and Sette,
A. MHC binding predications by ARB
matrix methods Š Automatic generation and evaluation of specific predictive
tools. Immunogenetics., In press.
304.
Sakai, A., Thimme, R.,
Spangenberg, H. C., Govindarajan, S., Farci, P., Purcell, R. H., Chisari, F.
V., and Bukh, J. In vivo analysis
of the HC-TN strain of HCV recovered from a case of fulminant hepatitis C: Relationship between disease phenotype,
host immune response, virus evaluation,
and outcome of infection. Submitted
305.
Yang, P.L., Althage, A,
Chung, J., Isogawa, M., and Chisari, F.V.
Requirement of FAS for the induction of HBV-Specific CTLs and clearance
of virus from the liver. Submitted.
306.
Kimura, K., Moriwaki,
H., Nagaki, M., Saio, M., Nakamoto, Y., Naito, M., and Chisari, F.V. CD40 Activated B Cells cause a
necroinflammatory liver disease in Mice.
Submitted.
307.
Iannacone, M., Sitia,
G., Isogawa, M., Castor, M., Lowenstein, P., Chisari, F.V., and Guidotti, L.G.
Platelets mediate CTL-induced immunopathology in the liver.
Submitted.
308.
Isogawa, M., Furuichi,
Y., and Chisari, F.V. Oscillating
CD8+ T cell effector functions following antigen recognition in the
liver. Submitted.
309.
Murray, J., Wieland, S.
F., and Chisari, F.V. Dynamics of acute hepatitis B virus infection and
clearance in chimpanzees. Submitted.
310.
Chisari, F.V.
Determinants of outcome of hepatitis C virus infection. Submitted
311.
Gilbert, R.J.C.,
Beales, L., Blond, D., Simon, M.N., Lin, B.Y., Chisari, F.V., Rowlands, D.J.,
and Stuart, D.I. Hepatitis B small surface antigen particles are
octahedral. Submitted.