1988

May 18 (Dyer) "Mechanisms of Peptide Hormone Signaling: An Immunoglobulin Gene Model", Dr. Marian E. Koshland, Department of Microbiology and Immunology, University of California, Berkeley, Berkeley, California 94720.

June 22 (Mider) "Basement Membranes: Key Determinants of Differentiation and Their Role in Cancer Metastasis", Dr. George Martin, Chief, Laboratory of Developmental Biology and Anomalies, National Institute of Dental Research, NIH.

November 2 (NIH) "RNA As An Enzyme", Dr. Thomas Cech, American Cancer Society, Professor University of Colorado at Boulder, Campus Box 215, Boulder, Colorado 80309-0215.

September 20 (NIH) "Analysis of Mammalian Gene Regulations in situ Using Retrovirus-Based Portable Exons", Dr. Stanley N. Cohen, Professor, Department of Genetics Stanford University School of Medicine, Stanford, California.

November 15 (Mider) "Switching Globin Genes On and Off: Chromatin Structure and Gene Expression", Dr. Gary Felsenfeld, Chief, Section on Physical Chemistry Laboratory of Molecular Biology, National Institute of Diabetes and Digestive Diseases, NIH.

January 17 (NIH) "Genes That Control Cholesterol", Dr. Michael S. Brown, Paul J. Thomas Professor of Genetics, Department of Molecular Genetics, The University of Texas, Southwestern Medical Center at Dallas, Dallas, Texas.

February 14 (Dyer) "Retroviruses: Where Did They Come From, and Where Are They Going?" Dr. Malcolm Martin, Chief, Laboratory of Molecular Microbiology National Institute of Allergy and Infectious Diseases, NIH.

October 11 (NIH) "Molecular Genetic Studies of Visual Pigments", Dr. Jeremy Nathans, Department of Molecular Biology and Genetics Johns Hopkins University School of Medicine.

November 14 (NIH) "Dystrophin Abnormalities in Neuromuscular Disease", Dr. Louis Kunkel, Professor of Genetics Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.

January 16 (Mider) "Memory Circuits", Dr. Mortimer Mishkin, Chief, Laboratory of Neuropsychology National Institute of Mental Health, NIH.

February 13 (NIH) "Mechanisms of Short-Term and Long-Term Memory", Dr. Daniel Koshland, Editor, Science, Washington D.C.

April 3 (Mider) "Gene Sharing: Lens Crystallins, Enzymes and Stress Proteins", Dr. Joram Piatigorsky, Chief, Laboratory of Molecular and Developmental Biology, National Eye Institute, NIH.

May 7 (Dyer) "A Comparative Analysis of T Cell Development", Dr. Mac D. Cooper, Howard Hughes Medical Institute, Research Laboratories, University of Alabama at Birmingham.

May 23 (NIH) "Molecular Genetics of Cancer Suppression", Dr. Wen-Hwa Lee, Professor, Department of Pathology, University of California, San Diego.

June 13 (NIH) "The Adrenergic Receptor", Dr. Robert Lefkowitz, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina.

November 19 (NIH) "Hematopoietic Stem Cells: Biological and Clinical Potentials", Dr. Irving L. Weissman, Professor of Pathology, Stanford University School of Medicine, Stanford, California

January 22 (NIH) "Molecular Analysis of Resistance to Anti-Cancer Drugs", Dr. Michael M. Gottesman, Chief, Laboratory of Cell Biology, Division of Cancer Biology, Diagnosis, and Centers, National Cancer Institute, NIH.

March 25 (Mider) "Human Gene Therapy", Dr. French Anderson, Chief, Molecular Hematology Branch, National Heart, Lung, and Blood Institute, NIH. Dr. R. Michael Blaese, Deputy Chief, Metabolism Branch National Cancer Institute, NIH. Dr. Steven A. Rosenberg, Chief of Surgery National Cancer Institute, NIH.

April 14 (Dyer) "The Alpha-Beta T Cell Repertoire in Health and Disease", Dr. Philippa C. Marrack, Department of Biochemistry and Biophysics, University of Colorado Medical Center, Denver, Colorado.

May 6 (NIH) "Splicing of Nuclear Precursors to Messenger RNAs", Dr. Phillip A. Sharp, Head, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts.

May 21 (NIH) "Creating Mice With Targeted Disruptions in Proto-oncogenes and Homeobox Genes", Dr. Mario Renato Capecchi, Department of Biology University of Utah School of Medicine, Salt Lake City, Utah.

January 7 (Cultural) "Federal Science and Technology Policy", The Honorable S. Allan Bromley, Ph.D., Assistant to the President for Science and Technology and Director, Office of Science and Technology Policy, Executive Office of the President, Washington, D.C.

January 26 (Mider) "Child Psychiatry and the Brain", Dr. Judith L. Rapoport, Chief, Child Psychiatry Branch, Division of Intramural Research, National Institute of Mental Health, NIH.

February 24 (NIH) "Protein NMR: Pushing Frontiers in Structural Biology", Adriaan Bax, Ph.D., Chief, Section on Biophysical Nuclear Magnetic Resonance Spectroscopy, Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH.

G. Marius Clore, M.D., Ph.D., Chief, Protein Nuclear Magnetic Resonance Section, Laboratory of Chemical Physics, NIDDK, NIH.

Angela M. Gronenborn, Ph.D., Chief, Structural Biology Section, Laboratory of Chemical Physics, NIDDK, NIH.

April 29 (NIH) "Iron, RNA, and Gene Expression: Solving the Dilemmas of a Toxic Nutrient", Richard D. Klausner, M.D., Chief, Cell Biology and Metabolism Branch, National Institute for Child Health and Human Development, NIH.

May 12 (Dyer) "Self-Recognition: Recent Insights Into the Deepest Puzzle in Immunology", Sir Gustav Nossal, M.D., Ph.D., Director, The Walter and Eliza Hall Institute of Medical Research, Professor of Medical Biology, The University of Melbourne Melbourne, Australia.

December 16 (Dyer) "Gene Therapy for AIDS: Fantasy or Feasibility", Flossie Wong-Staal, Ph.D., Florence Riford Chair in AIDS Research Professor Medicine and Biology University of California, San Diego, California.

February 11 (NIH) "Human Interferon Alphas: The Legend and the Legacy", Kathryn C. Zoon, Ph.D., Director, Center for Biologics Evaluation and Research, Food and Drug Administration. (This lecture was postponed to March 24.)

March 30 (Mider) "Transforming Growth Factor-Beth (TGF-b): Past, Present and Future", Michael B. Sporn, M.D., Chief, Laboratory of Chemoprevention and Anita B. Roberts, Ph.D., Deputy Chief, Laboratory of Chemprevention National Cancer Institute, NIH.

April 21 (NIH) "Regulation and Downstream Pathways of Growth Inhibitors", Patricia K. Donahoe, M.D., Chief, Pediatric Surgical Services and Director, Pediatric Surgical Research Laboratories Massachusetts General Hospital, Boston, Massachusetts.

June 1 (NIH) "Genetics of Human Breast Cancer", Mary-Claire King, Ph.D., Professor of Genetics Department of Molecular and Cell Biology, University of California - Berkeley, Berkeley, California.

June 8 (Cultural) "The Health of the Spirit", Jane Alexander, Chair, National Endowment for the Arts Washington, D.C.

October 5 "The Role of Peptides in the Selection of Thymoocytes", Dr. Susmu Tonegawa, Howard Hughes Medical Institute Massachusetts Institute of Technology.

October 12 "The Parallel Beta-Helices of Pectate Lyases and Implications for Infectious Agents", Dr. Frances Jurnak, University of California - Riverside.

October 26 (Pittman) "New Frontiers in Reproductive Biology and Contraceptive Vaccines", Dr. Bonnie S. Dunbar, Baylor College of Medicine.

November 2 "Costimulatory Molecules B7-1 and B7-2 Differently Affect T-helper Development and Autoimmunity," Dr. Laurie H. Glimcher, Harvard University.

November 9 "Cell Cycle Check Points and Cancer", Leland H. Hartwell, University of Washington.

November 30 "Role of Apoptosis and Cancer Treatment", David E. Housman, Massachusetts Institute of Technology.

December 7 "The Role of NF-kB in the Immune Response", David Baltimore, Massachusetts Institute of Technology.

December 14 "Lyme Disease", Allen C. Steere, Tufts University.

December 21 "The Bacterial Flagellum--Nature's Rotary Motor", David J. DeRosier, Brandeis University.

January 4 (Dyer) "Macromolecular Associations and Signal Transduction", Henry Metzger, Scientfic Director, National Institute for Arthiritis and Musculoskeletal Diseases, NIH.

January 11 "Control of Cell Cycle Progression and Cell Polarity in Yeast", Ira Herskowitz, University of California - San Francisco.

January 18 (Mider) "Brain Maps for Eye Movement", Robert H. Wurtz, Chief, Laboratory of Sensorimotor Research National Eye Institute, NIH.

January 25 "G Proteins and Regulation of Adenylyl Cyclases", Alfred G. Gliman, University of Texas.

February 1 "Regulation of Tyrosine Phosphorylaiton by Integrin Receptors", Joan S. Brugge, Ariad Pharmaceuticals, Inc.

February 8 "Neural Grafting in Parkinson's Disease", Anders Björkland, Lund. "Surgical Approaches to Parkinson's Disease", R. Delong, Emory University.

February 15 "Rendering the Brain Resistant to Stroke", Dennis W. Choi, Washington University.

February 22 "Membrane Trafficking in the Nerve Terminal", Richard H. Scheller, Howard Hughes Medical Institute Stanford University, Palo Alto, California.

May 17 (NIH) "Brain Waves and Brain Wiring", Dr. Carla Schatz, Professor of Neurobiology, Howard Hughes Medical Institute Investigator Department of Molecular and Cell Biology, University of California - Berkeley, Berkeley, California.

May 24 (NIH) "Altering Telomerase RNA: Enzymatic and Cellular Consequences", Dr. Elizabeth Blackburn, Professor and Chair Department of Microbiology and Immunology University of California - San Francisco, San Francisco, California.

February 28 (Pittman) "BMPs: Multifunctional Regulators of Embryonic Development", Dr. Brigid M. Hogan, Howard Hughes Medical Institute Investigator, and Hortense B. Ingram Professor, Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee.

March 19 (NIH) "Inductive Signals and the Control of Neural Cell Fate", Dr. Thomas Jessell, College of Physicians and Surgeons Columbia University, New York, New York.

March 26 (NIH) "Protein Traffic Into and Out of the Nucleus", Dr. Gunter Blobel, Department of Cell Biology Rockefeller University, New York, New York.

April 3 "Hetrotirmeric G. Proteins, Transmitters and Tuners for Membrane and Signals", Dr. Eva J. Neer, Professor of Medicine (Biochemistry) Harvard Medical School, Boston, Massachusetts. April 10 (Dyer) "Lymphocyte Survival", Dr. Harold von Boehmer, Faculty of Medenice Necker ,156 Rue de Vagirard, 75730 Paris Cedex 15, Paris, France.

April 23 (Dyer) "Something Old and Something New, Something Borrowed and Some Things Yet To Do," Dr. John Robbins, Chief, Laboratory of Developmental and Molecular Immunity, National Institute for Child Health and Human Development, NIH.

June 6 (NIH) "From Simplicity to Complexity", Dr. Murray Gell-Mann, Professor and Co-Chairman of Science Board, Santa Fe Institute, Santa Fe, Mew Mexico.

October 28 (Cultural) "Women and Men in Conversation: A Linguistic Approach" Dr. Deborah Tannen, Department of Linguistics, Georgetown University, Washington, D.C. November 20 (Mider) "What Chronic Granulomatous Disease Has Taught Us About Oxidative Metabolism Interferon-y, and Gene Therapy", Dr. John Gallin, Director, Clinical Center, NIH.

June 4 (Pittman) "Control of Intracellular Membrane Traffic: Involvement of G Proteins and GAIP and RGS Protein," Marilyn G. Farguhar, Ph.D., Professor of Pathology and Coordinator, Division of Cellular and Molecular Medicine University of California - San Diego, La Jolla, California.

September 10 (Dyer) "Cell Death and the Regulation of Homeostasis" Stanley Korsmeyer, M.D. Howard Hughes Medical Institute Investigator, Professor of Medicine and Pathology, School of Medicine,Washington University, St. Louis, Missouri.

September 17 (Pittman) "Alpha2-adrenergic Receptors Achieve Signaling Specificity Via Coupling to Distinct Effectors and Targeting to Discrete Surface Domains", Lee E. Limbird, Ph.D., Professor and Chair, Department of Pharmacology Center for Molecular Neuroscience, Vanderbilt University School of Medicine, Nashville, Tennessee.

November 19 "New Directions in Angiogenesis Research", Judah M. Folkman, M.D., Children's Hospital of Boston and Harvard Medical School, Boston, Massachusetts.

February 4 "Protein Modules in Signal Transduction" Anthony J. Pawson, Ph.D., Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Canada.

February 25 (Mider) "Neural Mechanisms of Human Cognition: Insights from Brain Imaging Studies." Leslie G. Ungerleider, Acting Chief, Laboratory of Psychology and Psychopathology, National Institute of Mental Health, NIH.

June 25 (Cultural) Robert Pinsky 39th United States Poet Laureate and Professor of Graduate Writing, Boston University. Poetry Reading with Commentary.

November 4 (Cultural) Steven Pinker, Ph.D. Director, McDonnell-Pew Center for Cognitive Neuroscience, MIT. "Words and Rules: The Ingredients of Language".

November 18 (Pittman) Carol Prives, Professor, Department of Biological Sciences Columbia University of Physicians and Surgeons. "Signaling to the p53 Tumor Suppressor Protein."

February 17 (NIH) "Deconstructing Smell." Linda Buck, Ph.D.,Associate Professor of Neurobiology and HHMI Associate Investigator, Harvard Medical School.

April 28 (Dyer) "Anti-Cytokine Therapies for Inflammatory Diseases." Charles Dinarello, M.D., Professor of Medicine, Division of Infectious Disease, UCHSC

June 2 (Cultural) "Conflicting Principles of Health Evaluation." Amartya K. Sen, Ph.D., 1998 Nobel Laureate in Economics and Master, Trinity College, Cambridge, UK.