Demystifying Medicine

Course Materials for 2008

1. January 8, 2008, "HIV/AIDS: The ultimate chameleon"
   
   • Arias introduction
   • Coffin presentation
   • Masur presentation
     
     
2. January 15, 2008, "Coronary Heart Disease: Detecting and treating a major killer"
   
   • Balaban presentation
   • Sack presentation
   • Rosing presentation
     
     
3. January 22, 2008, "Cystic diseases and cilia: A new frontier"
   
   • Gunay-Aygun presentation
   • Ott presentation
   • Readings:
     • Satir P, Christensen ST. 2007. Overview of Structure and Function of Mammalian Cilia. Annu. Rev. Physiol.  69:377-400 (PDF, 779 KB)
     • Torres VE, Harris PC. 2007. Polycystic kidney disease: genes, proteins, animal models, disease mechanisms and therapeutic opportunities. J. Intern. Med.  261; 17-31 (PDF, 880 KB)
     • Wheatley DN. 2005. Landmarks in the first hundred years of primary (9 + 0) cilium research. Cell Biol. Int.  29:333-339 (PDF, 359 KB)
     • Yoder BK. 2007. Role of Primary Cilia in the Pathogenesis of Polycystic Kidney Disease. J. Am. Soc. Nephrol.  18:1381-1388 (PDF, 491 KB)
   • Normal respiratory epithelia video (MPEG stream, 1.6 MB)
   • Abnormal respiratory epithelia video (MPEG stream, 1.6 MB)
   • Normal sperm video (AVI stream, 3.1 MB)
   • Dysmotile sperm video (AVI stream, 3.4 MB)
     
     
4. January 29, 2008, "Diseases from the blood bank: Progress and the future"
   
   • Klein presentation
   • Alter presentation
     
     
5. February 5, 2008, "Inflammatory bowel diseases: What is the target?"
   
   • Strober presentation
   • Mannon presentation
     
     
6. February 12, 2008, "Malaria: Big killer and big advances"
   • Arias introduction
   • Robbins presentation
   • Readings
     • Brown D. 2008. Anti-Malaria Efforts Yield New Success. Washington Post,  Feb. 1, 2008 (PDF, 4.19 MB)
     • Cholera R, et al. 2008. Impaired cytoadherence of Plasmodium falciparum-infected erythrocytes containing sickle hemoglobin. P.N.A.S.  vol. 105, no. 3, 991–996. (PDF, 691 KB)
   • Malaria Atlas Project (MAP)
     
     
7. February 19, 2008, "Hunger, appetite, obesity, addiction: The new pandemic"
   • Volkow presentation
   • Skarulis presentation
     
     
8. February 26, 2008, "Diabetes and autoimmunity: Turning against self"
   • Notkins presentation
     
     
9. March 4, 2008, "West Nile Virus: A new threat"
   • Agrawal presentation
   • Murphy presentation
     
     
10. March 11, 2008, "Genetic screening: Finding Mendelian disease genes"
    • Biesecker/Sapp presentation
      
      
11. March 18, 2008, "Neurologic diseases in the genomic era"
    • Arias introduction
    • Singleton presentation
    • Gwinn presentation
      
      
12. March 25, 2008, "Cystic fibrosis: A common inheritable disease with many unknowns"
    • Collins/Milgram presentation
    • Milgram presentation
      
      
13. April 1, 2008, "Lysosomal diseases: Patients and problems"
    • Huizing/Gahl/Westbroek presentation
      
      
14. April 8, 2008, "Gaucher's disease: Treating a genetic disease"
    • Sidransky/Austin presentation
      
      
15. April 15, 2008, "Traumatic brain injury: Mechanisms, treatment and challenges"
    • Chan presentation
    • Koroshetz presentation
    • Engel presentation
    • Jaffee presentation
    • Reading:
      • Hoge C, et al. 2008. Mild Traumatic Brain Injury in U.S. Soldiers Returning from Iraq. N. Engl. J. Med.  358(5):525-7
      
      
16. April 22, 2008, "Brain cancer: Problems and progress"
    • Fine presentation
      
      
17. April 29, 2008, "Liver cancer: A global problem. Who gets THE liver transplant?"
    • Arias introduction
    • Ghany presentation
    • Wertheimer presentation
    • References:
      • Thorgeirsson S.S. and Grisham J.W. (2002). Molecular pathogenesis of human hepatocellular carcinoma. Nat. Genet. 31: 339-346.
      • Kim J.W. and Wang X.W. (2003). Gene expression profiling of preneoplastic liver disease and liver cancer: A new era for improved early detection and treatment of these deadly diseases? Carcinogenesis 24: 363-369.
      • Budhu A., Forgues M., Ye Q.H., Jia L.H., He P., Zanetti K.A., Kammula U.S., Chen Y., Qin L.X., Tang Z.Y., et al. (2006). Prediction of venous metastases, recurrence and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment. Cancer Cell 10: 99-111.
      • Budhu A., Jia H.L., Forgues M., Liu C.G., Goldstein D., Lam A., Zanetti K.A., Ye Q.H., Qin L.X., Croce C.M., et al. (2008). Identification of metastasis-related microRNAs in hepatocellular carcinoma. Hepatology 47: 897-907.
      
      
18. May 6, 2008, "Lung cancer: Clinical progress and the cancer stem cell paradigm"
    • Giaccone presentation
    • Varticovski presentation
      
      
19. May 13, 2008, "Finale: What does the future hold for PhD postdoctoral fellows?"
    
    

This web page was last modified on May 15, 2008. For questions about the course, please contact ariasi@mail.nih.gov.